The risk of TB re-infection can easily increase by Anti-TB drugs
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| Anti-TB Drugs |
Treatment leads to changes in gut bacteria
Current treatments for tuberculosis(TB) are very effective in controlling TB infections which is caused by Mycobacterium tuberculosis (Mtb) & however they may not always prevent reinfection.
What is the reason for which Anti-TB drugs may not prevent reinfections is one of the long-standing question in TB Research
Anti-tuberculosis drugs cause changes to gut microbiota and increase susceptibility to Mycobacterium tuberculosis(Mtb) is a major reason for which current treatments are ineffective in preventing reinfections.
Current treatments for tuberculosis(TB) are very effective in controlling TB infections which is caused by Mycobacterium tuberculosis (Mtb) & however they may not always prevent reinfection.
What is the reason for which Anti-TB drugs may not prevent reinfections is one of the long-standing question in TB Research
Anti-tuberculosis drugs cause changes to gut microbiota and increase susceptibility to Mycobacterium tuberculosis(Mtb) is a major reason for which current treatments are ineffective in preventing reinfections.
Why are human bodies unable to generate permanent immunity to TB ?
A team of scientists at the Research Institute
of the McGill University Health Centre (RI-MUHC) and McGill University doing
research in Mucosal Immunology, they showed that
anti-TB drugs caused changes to gut microbiota which is the diverse community
of microbes living our intestines and
increased susceptibility to Mtb infection.
Gut microbiota
- critical to keeping us healthy
- help to digest food
- combat pathogenic microbes
- reinforce our immune system
Recent research has shown that chronic use of antibiotic leads to disruption of this community, which can in turn lead to dysregulation of the immune system. It remains unclear, however, whether changes in the composition of the microbes living in our gut have an influence on TB infection.
Dr. Irah King and Maziar Divangahi from the Meakins-Christie Laboratories at the RI-MUHC, with colleagues from McGill's Macdonald Campus, treated mice with the most commonly used anti-TB drugs - isoniazid, rifampicin and pyrazinamide.
Researchers are already thinking of monitoring patients who are being treated with these drugs to see how their gut microbiota changes over time and once treatment has stopped. The idea will be to control changes to the microbiome in combination with drugs that are effective at killing Mtb.
Key Resource: McGill University, Journals
September 11-12, 2019 Singapore
Theme: Accelerations and Decelerations in Drug Discovery
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